Hydrocodone white grapefruit juice9/1/2023 ![]() Safety and efficacy have not been established.Īppropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of hydrocodone and acetaminophen combination oral solution in children 2 years of age and older. For non-prescription products, read the label or package ingredients carefully.Īppropriate studies have not been performed on the relationship of age to the effects of hydrocodone and acetaminophen combination capsules and tablets in the pediatric population. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. For this medicine, the following should be considered: Allergies This is a decision you and your doctor will make. In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This product is available in the following dosage forms: This medicine is available only under a restricted distribution program called the Opioid Analgesic REMS (Risk Evaluation and Mitigation Strategy) program. However, severe withdrawal side effects can usually be prevented by gradually reducing the dose over a period of time before treatment is stopped completely. Physical dependence may lead to withdrawal side effects if treatment is stopped suddenly. Mental dependence (addiction) is not likely to occur when narcotics are used for this purpose. However, people who have continuing pain should not let the fear of dependence keep them from using narcotics to relieve their pain. When hydrocodone is used for a long time, it may become habit-forming, causing mental or physical dependence. It acts on the central nervous system (CNS) to relieve pain, and stops or prevents cough. Hydrocodone belongs to the group of medicines called narcotic analgesics (pain medicines). But acetaminophen may cause other unwanted effects when taken in large doses, including liver damage. ![]() It does not become habit-forming when taken for a long time. Thus, colored grapefruit juice may produce drug interactions at the same rate as white grapefruit juice.Acetaminophen is used to relieve pain and reduce fever in patients. White samples inhibited CYP3A-mediated testosterone-6beta oxidation in human liver microsomes by 1.04 and 0.922 times (whole juice and furanocoumarin, respectively) the inhibition by colored juice. The mean difference in bergaptol, bergamottin, and 6',7'-dihydroxybergamottin concentrations in white grapefruit juice samples was 1.59, 0.902, and 1.03 times, respectively, the amounts in colored samples. We measured concentrations of three major furanocoumarin derivatives, bergaptol, bergamottin, and 6',7'-dihydroxybergamottin, with high-performance liquid chromatography in 21 brands of grapefruit juice sold in Japan, including 14 white and 7 colored brands. Therefore, we examined the potential interactions of both white and colored grapefruit products by measuring the concentrations of furanocoumarin derivatives and inhibition of the metabolizing cytochrome P450 (CYP) 3A enzymes, the target of the furanocoumarins. However, few studies have examined interactions with colored juice products. Colored (pink and red) grapefruit pulp contains lower amounts of the furanocoumarin derivatives that cause pharmacokinetic interactions than white grapefruit pulp.
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